This book aligns with the PCI regulations, 2014. This practical component has two parts,modern analytical techniques and pharmaceutics. This attempt concentrates on the pharmaceutics part.

   Special emphasis is laid on the selection of drugs, excipients and methodologies, for conducting assignments with rationalization. The manual is designed to keep the content cohesively and support aspects are separately reported, in Appendixes A, B, and C. Appendix A provides supplementary information, Appendix B covers the analytical methods and Appendix C details the preparations of reagents. An attempt is made to model the dissolution profiles through computer-aided analysis (DDSolver).

   Special emphasis is given on the lines of expectations.
         1. Applications of concepts and principles to pharmacy.
         2. Independent processing of raw data, through model calculations.
         3. Illustrations organized the laboratory work.
         4. A question bank for guiding students to perform viva voce well.

EXPERIMENTS

  1. Micromeritic properties of powders and granules

  2. Effect of binders on the performance of tablets

  3. Effect of compressional force on
      disintegration time of tablets.

  4. In vitro dissolution of controlled/sustained
      release marketed formulations

  5A. Drug release kinetics analysis
        – MS Excel package

  5B. Drug release mechanisms analysis
        – MS Excel package

  5C. Drug release profiles comparison
        – Dissolution efficiency

  5D. Drug release profiles comparison
        – Mean dissolution time

  5E. Drug release profiles comparison
        – Similarity factor (f2)

  6. Analysis of tablet compression forces
        – Heckel plots

  7A. Drug release kinetics analysis
        – DDSolver package

  7B. Drug release mechanisms analysis
        – DDSolver package

  7C. Drug release profiles comparison
        – DDSolver package

  8. Formulation and evaluation of
      diclofenac floating matrix tablets

  9. Formulation and evaluation of
      sustained release matrix tablets

10. Formulation and evaluation of
      buccal mucoadhesive films

11. Formulation and evaluation of
      diclofenac osmotic drug delivery system

12. Formulation and evaluation of
      diclofenac transdermal patches

13. Effect of particle size
      on the drug dissolution

14. Preformulation studies of tablets

Appendix A – Support to Experiments
Appendix B – Analytical Methods for Estimation of Drugs
Appendix C – Reagents and Preparations

Bibliography
Subject Index